Cyclacel Pharmaceuticals (NASDAQ:CYCC – Get Free Report) and Lexicon Pharmaceuticals (NASDAQ:LXRX – Get Free Report) are both small-cap medical companies, but which is the superior business? We will contrast the two businesses based on the strength of their earnings, risk, valuation, dividends, institutional ownership, profitability and analyst recommendations.
Earnings & Valuation
This table compares Cyclacel Pharmaceuticals and Lexicon Pharmaceuticals’ gross revenue, earnings per share and valuation.
| Gross Revenue | Price/Sales Ratio | Net Income | Earnings Per Share | Price/Earnings Ratio | |
| Cyclacel Pharmaceuticals | $420,000.00 | 5.62 | -$22.56 million | ($27.22) | -0.07 |
| Lexicon Pharmaceuticals | $1.20 million | 338.58 | -$177.12 million | ($0.80) | -2.06 |
Cyclacel Pharmaceuticals has higher earnings, but lower revenue than Lexicon Pharmaceuticals. Lexicon Pharmaceuticals is trading at a lower price-to-earnings ratio than Cyclacel Pharmaceuticals, indicating that it is currently the more affordable of the two stocks.
Analyst Recommendations
| Sell Ratings | Hold Ratings | Buy Ratings | Strong Buy Ratings | Rating Score | |
| Cyclacel Pharmaceuticals | 0 | 1 | 1 | 0 | 2.50 |
| Lexicon Pharmaceuticals | 0 | 1 | 0 | 0 | 2.00 |
Cyclacel Pharmaceuticals presently has a consensus price target of $21.00, indicating a potential upside of 1,073.18%. Lexicon Pharmaceuticals has a consensus price target of $5.00, indicating a potential upside of 203.03%. Given Cyclacel Pharmaceuticals’ stronger consensus rating and higher probable upside, equities analysts plainly believe Cyclacel Pharmaceuticals is more favorable than Lexicon Pharmaceuticals.
Institutional & Insider Ownership
23.6% of Cyclacel Pharmaceuticals shares are owned by institutional investors. Comparatively, 74.7% of Lexicon Pharmaceuticals shares are owned by institutional investors. 8.5% of Cyclacel Pharmaceuticals shares are owned by insiders. Comparatively, 6.8% of Lexicon Pharmaceuticals shares are owned by insiders. Strong institutional ownership is an indication that hedge funds, large money managers and endowments believe a company is poised for long-term growth.
Profitability
This table compares Cyclacel Pharmaceuticals and Lexicon Pharmaceuticals’ net margins, return on equity and return on assets.
| Net Margins | Return on Equity | Return on Assets | |
| Cyclacel Pharmaceuticals | N/A | -448.19% | -151.29% |
| Lexicon Pharmaceuticals | -14,573.20% | -138.54% | -71.29% |
Risk & Volatility
Cyclacel Pharmaceuticals has a beta of 0.54, indicating that its share price is 46% less volatile than the S&P 500. Comparatively, Lexicon Pharmaceuticals has a beta of 1.27, indicating that its share price is 27% more volatile than the S&P 500.
About Cyclacel Pharmaceuticals
Cyclacel Pharmaceuticals, Inc., a clinical-stage biopharmaceutical company, develops medicines for the treatment of cancer and other proliferative diseases. The company's lead product includes fadraciclib, a cyclin dependent kinase Inhibitors (CDK) that is in Phase 1/2 clinical trial for the treatment of solid tumors, as well as in combination with venetoclax to treat relapsed or refractory chronic lymphocytic leukemia; and Plogosertib, a polo-like kinase inhibitor program, which is in Phase 1/2 clinical trial for the treatment of advanced leukemias and solid tumors. It has a clinical collaboration agreement with the University of Texas MD Anderson Cancer Center to clinically evaluate the safety and efficacy of three cyclacel medicines in patients with hematological malignancies, including chronic lymphocytic leukemias, acute myeloid leukemias, myelodysplastic syndromes, and other advanced leukemias. The company was founded in 1996 and is headquartered in Berkeley Heights, New Jersey.
About Lexicon Pharmaceuticals
Lexicon Pharmaceuticals, Inc., a biopharmaceutical company, focuses on the discovery, development, and commercialization of pharmaceutical products. Its orally-delivered small molecule drug candidates under development comprise Sotagliflozin that completed Phase III clinical trials for the for the treatment of heart failure and type 1 diabetes; and LX9211, which is in Phase II clinical development for the treatment of neuropathic pain and LX2761, which is in Phase I clinical development for gastrointestinal tract. Lexicon Pharmaceuticals, Inc. has strategic collaboration and license agreements with Bristol-Myers Squibb Company and Genentech, Inc. The company was incorporated in 1995 and is headquartered in The Woodlands, Texas.
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