Seer, Inc. (NASDAQ:SEER) Short Interest Up 126.6% in February

Seer, Inc. (NASDAQ:SEER) was the recipient of a significant increase in short interest during the month of February. As of February 13th, there was short interest totaling 634,111 shares, an increase of 126.6% from the January 29th total of 279,780 shares. Based on an average trading volume of 352,140 shares, the short-interest ratio is currently 1.8 days. Approximately 1.3% of the company’s stock are sold short. Approximately 1.3% of the company’s stock are sold short. Based on an average trading volume of 352,140 shares, the short-interest ratio is currently 1.8 days.

Key Headlines Impacting Seer

Here are the key news stories impacting Seer this week:

• Positive Sentiment: Q4 EPS beat — Seer reported ($0.29) EPS vs. consensus ($0.32), and Q4 gross margin remained healthy (≈52%), showing operational progress despite losses. Seer Reports Fourth Quarter and Full Year 2025 Financial Results and Provides Full Year 2026 Outlook
• Positive Sentiment: Installed base and cash position are strong — Seer grew its Proteograph installed base to 82 instruments (67% YoY) and ended 2025 with ≈$240.6M in cash/investments, giving runway to execute. Seer, Inc. Reports Fourth Quarter and Full Year 2025 Financial Results with Revenue Growth and Expanded Instrument Base
• Positive Sentiment: Board actions support shareholder value — Seer’s board approved a limited buyback program and adopted an NOL preservation plan to protect ≈$262M of tax assets, which can preserve future tax offsets. Seer outlines $16M–$18M 2026 revenue target as product innovation accelerates and new buyback approved Seer Adopts Limited Duration Tax Benefit Preservation Plan
• Neutral Sentiment: Full earnings materials and call transcript are available for review — useful for investors wanting color on kit pull‑through, instrument sales cadence, and pipeline. Seer (SEER) Q4 2025 Earnings Call Transcript
• Negative Sentiment: 2026 guidance materially below consensus — Seer guided to $16M–$18M revenue for 2026 (midpoint ≈$17M) versus analyst consensus near $22.1M, signaling modest growth and raising near‑term expectations risk. Seer Reports Fourth Quarter and Full Year 2025 Financial Results and Provides Full Year 2026 Outlook
• Negative Sentiment: Large ongoing losses and revenue shortfall — FY‑2025 net loss was $73.6M and Q4 revenue of $4.2M missed analyst revenue expectations, keeping profitability distant and relying on continued cash reserves. Seer Reports Fourth Quarter and Full Year 2025 Financial Results and Provides Full Year 2026 Outlook
• Negative Sentiment: Short interest rose sharply in February (≈126% increase), which may add volatility and reflect bearish positioning. (Short interest data reported Feb. 25)

Analyst Ratings Changes

Several equities analysts have recently issued reports on SEER shares. Weiss Ratings reaffirmed a “sell (d-)” rating on shares of Seer in a research report on Thursday, January 22nd. Wall Street Zen raised shares of Seer to a “hold” rating in a report on Saturday, December 13th. One equities research analyst has rated the stock with a Sell rating, According to data from MarketBeat.com, the company currently has an average rating of “Sell”.

Seer Stock Performance

NASDAQ SEER opened at $2.08 on Friday. Seer has a one year low of $1.62 and a one year high of $2.41. The stock has a 50-day moving average of $1.90 and a 200 day moving average of $2.02. The company has a market capitalization of $116.04 million, a price-to-earnings ratio of -1.53 and a beta of 1.63.

Seer (NASDAQ:SEER) last posted its earnings results on Thursday, February 26th. The company reported ($0.29) earnings per share (EPS) for the quarter, beating the consensus estimate of ($0.32) by $0.03. Seer had a negative net margin of 484.51% and a negative return on equity of 25.88%. The business had revenue of $4.20 million for the quarter, compared to analysts’ expectations of $4.60 million. On average, equities analysts predict that Seer will post -1.42 earnings per share for the current fiscal year.

Institutional Investors Weigh In On Seer

Hedge funds have recently added to or reduced their stakes in the stock. Goldman Sachs Group Inc. lifted its holdings in shares of Seer by 51.6% during the 1st quarter. Goldman Sachs Group Inc. now owns 170,897 shares of the company’s stock valued at $289,000 after buying an additional 58,173 shares during the period. Jane Street Group LLC boosted its position in Seer by 33.3% in the first quarter. Jane Street Group LLC now owns 254,174 shares of the company’s stock worth $430,000 after purchasing an additional 63,432 shares during the last quarter. Geode Capital Management LLC grew its stake in shares of Seer by 16.5% during the 2nd quarter. Geode Capital Management LLC now owns 509,727 shares of the company’s stock valued at $1,091,000 after purchasing an additional 72,265 shares during the period. XTX Topco Ltd purchased a new stake in shares of Seer during the 2nd quarter valued at about $172,000. Finally, Quadrature Capital Ltd purchased a new stake in shares of Seer during the 2nd quarter valued at about $47,000. 75.20% of the stock is currently owned by hedge funds and other institutional investors.

About Seer

Seer, Inc is a life sciences company focused on pioneering next-generation proteomics, the large-scale study of proteins and their functions in complex biological systems. By leveraging proprietary nanoparticle-based technology, Seer’s platform enables high-throughput, unbiased protein analysis from biological samples, addressing a critical bottleneck in drug discovery, biomarker research and precision medicine.

The company’s flagship Proteograph Product Suite combines engineered nanoparticle assays with advanced mass spectrometry and bioinformatics pipelines to deliver deep proteomic coverage in a scalable workflow.