Trevi Therapeutics (NASDAQ:TRVI – Get Free Report) and Atea Pharmaceuticals (NASDAQ:AVIR – Get Free Report) are both small-cap medical companies, but which is the better investment? We will contrast the two businesses based on the strength of their valuation, earnings, dividends, profitability, risk, institutional ownership and analyst recommendations.
Analyst Ratings
This is a breakdown of current ratings and price targets for Trevi Therapeutics and Atea Pharmaceuticals, as reported by MarketBeat.com.
| Sell Ratings | Hold Ratings | Buy Ratings | Strong Buy Ratings | Rating Score | |
| Trevi Therapeutics | 1 | 0 | 8 | 2 | 3.00 |
| Atea Pharmaceuticals | 1 | 1 | 0 | 1 | 2.33 |
Trevi Therapeutics presently has a consensus target price of $21.10, indicating a potential upside of 76.72%. Atea Pharmaceuticals has a consensus target price of $6.00, indicating a potential downside of 1.64%. Given Trevi Therapeutics’ stronger consensus rating and higher probable upside, analysts clearly believe Trevi Therapeutics is more favorable than Atea Pharmaceuticals.
Earnings and Valuation
| Gross Revenue | Price/Sales Ratio | Net Income | Earnings Per Share | Price/Earnings Ratio | |
| Trevi Therapeutics | N/A | N/A | -$47.91 million | ($0.37) | -32.27 |
| Atea Pharmaceuticals | N/A | N/A | -$158.35 million | ($1.94) | -3.14 |
Trevi Therapeutics is trading at a lower price-to-earnings ratio than Atea Pharmaceuticals, indicating that it is currently the more affordable of the two stocks.
Institutional and Insider Ownership
95.8% of Trevi Therapeutics shares are owned by institutional investors. Comparatively, 86.7% of Atea Pharmaceuticals shares are owned by institutional investors. 18.3% of Trevi Therapeutics shares are owned by insiders. Comparatively, 18.1% of Atea Pharmaceuticals shares are owned by insiders. Strong institutional ownership is an indication that large money managers, hedge funds and endowments believe a company is poised for long-term growth.
Profitability
This table compares Trevi Therapeutics and Atea Pharmaceuticals’ net margins, return on equity and return on assets.
| Net Margins | Return on Equity | Return on Assets | |
| Trevi Therapeutics | N/A | -31.23% | -29.32% |
| Atea Pharmaceuticals | N/A | -46.34% | -42.52% |
Risk and Volatility
Trevi Therapeutics has a beta of 0.94, suggesting that its stock price is 6% less volatile than the S&P 500. Comparatively, Atea Pharmaceuticals has a beta of 0.21, suggesting that its stock price is 79% less volatile than the S&P 500.
Summary
Trevi Therapeutics beats Atea Pharmaceuticals on 11 of the 12 factors compared between the two stocks.
About Trevi Therapeutics
Trevi Therapeutics, Inc., a clinical-stage biopharmaceutical company, focuses on the development and commercialization of therapy Haduvio for the treatment of chronic cough in idiopathic pulmonary fibrosis (IPF) and refractory chronic cough (RCC) conditions targeting the central and peripheral nervous systems. The company is developing Haduvio, an oral extended-release formulation of nalbuphine, which is in phase 2b Cough Reduction in IPF with nalbuphine ER (CORAL) clinical trial for treatment of chronic cough in patients with IPF; phase 2a Refractory Chronic Cough Improvement Via NAL ER (RIVER) clinical trial for reducing chronic cough in RCC patients; phase 2 clinical trial in patients with pruritus; phase 2b/3 clinical trial in patients with prurigo nodularis. It has a license agreement with Endo Pharmaceuticals Inc. to develop and commercialize products incorporating nalbuphine hydrochloride in any formulation. The company was incorporated in 2011 and is headquartered in New Haven, Connecticut.
About Atea Pharmaceuticals
Atea Pharmaceuticals, Inc., a clinical-stage biopharmaceutical company, discovers, develops, and commercializes antiviral therapeutics for patients with viral infections. Its lead product candidate is AT-527, an oral antiviral candidate that is in Phase 3 SUNRISE-3 clinical trial for the treatment of patients with COVID-19. The company also develops bemnifosbuvir in combination with ruzasvir, which is in Phase 2 clinical trial, for the treatment of hepatitis C virus (HCV); and a protease inhibitor for the treatment of COVID-19. It has a license agreement with MSD International GmbH for the development, manufacture, and commercialization of Ruzasvir, an NS5A inhibitor, for the treatment of HCV. Atea Pharmaceuticals, Inc. was incorporated in 2012 and is headquartered in Boston, Massachusetts.
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